The 16th World Congress on Endometriosis 2025 (WCE 2025) kicked off on May 21, 2025, at Darling Harbour in Sydney, Australia. Lasting for 4 days, the conference concluded successfully on May 24, 2025. It attracted over 1,000 delegates from 43 countries, including top experts in the global endometriosis field who presented the most cutting-edge research findings. The agenda was splendid, featuring lectures and discussions in various modules focusing on endometriosis pathogenesis theories, diagnostic targets, treatment, and related social-mental health issues. Special sessions such as the China-Australia Special Session, India-Australia Special Session, and European Endometriosis League (EEL) Special Session were also set up to promote academic exchanges among scholars from different countries. In addition to inviting experts and scholars to give oral presentations, the conference venue included a poster research gallery and roundtable discussion sessions, integrating diverse academic exchange formats. This push summarizes some wonderful moments of the conference and provides a brief share for readers.